Computational Repurposing of Chemotherapies for Pulmonary Hypertension
The clinical care of neglected diseases such as pulmonary hypertension (PH) has not yet benefited from large scale –omics data analysis. Evidence suggests parallels in the pathogenesis of cancer, where –omics data are available, and PH, thus making a repurposing of chemotherapeutics for PH possible. This proposal leverages a network-based analysis of cancer –omics data to predict in silico and define experimentally which chemotherapies may offer the most robust actions in PH.