Drug Discovery Institute (UPDDI)

W950 Biomedical Science Tower
200 Lothrop Street

Vision for the University of PIttsburgh Drug Discovery Institute: Optimizing the discovery and development of new molecular entities through collaborations between faculty, academic centers, corporations and government agencies, together with innovations focused on Quantitative Systems Pharmacology (QSP).

The UPDDI has three major classes of activities: a) integrated programs that apply QSP to metastatic breast cancer, Huntington’s Disease (as a first focus area to be extended  to other neurodegenerative diseases) and liver diseases; b) projects based on ligand- or target-centric discovery that are driven by faculty collaborators/ RO1 grants covering many therapeutic areas; and c) translational technology development including companion diagnostics, computational biology/chemistry tools, analytics to identify and quantify heterogeneity in experimental and clinical samples and advanced human tissue models for discovery.  The UPDDI is positioned in an outstanding environment to translate key scientific and clinical advances into novel therapeutics.  

Resources include:

Discovery Technology

Chemistry/Medicinal Chemistry

Computational Biology & Chemistry

Zebrafish Facility

Preclinical Resources

Chemical Biology Facility

Research Category