Research Resources - Laboratory and Computing

This directory provides links or contact information for laboratory, computing, and data analysis resources that are available to University investigators. 

To submit updates, or to request the addition of a resource, please contact Paul Wood at pgw@pitt.edu or (412) 648-9618.

 

For Pitt Biomedical Research Facilities' web site search.

View Resources by Category

Biomedical Mass Spectrometry Center

9th Floor (9034) Biomedical Science Tower 3
412-648-1811
F: 412-383-5937
Website

The Biomedical Mass Spectrometry (BioMS) Center is a campus-wide shared facility dedicated to advancing the use and application of mass spectrometry in basic, translational, and clinical research. The center combines state-of-the-art high resolution mass spectrometry with classical biochemical approaches to identify and quantify biologically relevant proteins.  

Not sure how to get started? 

The BioMS center helps newcomers get started fast, by offering an in-gel protein identification service. Cut out your coomassie stained gel band and get it to us by noon on Monday and we will send you a list of identified proteins and post-translational modifications the following week.

Make us an extension of your lab.

Sometimes there is no substitute for doing it yourself. Faculty and students that want to gain first hand mass spectrometry experience are encouraged to work alongside the expert staff and other users in the center. We provide the bench space, instrumentation, and expertise. You provide the excitement and energy.

Want to discuss a specific project? 

Nathan Yates (Center Director) and Xuemei Zeng (Asst. Director for Proteomics) regularly meet with investigators to discuss and plan collaborative research projects. To schedule a meeting, contact Dr. Nathan Yates.  

Biomedical Research Imaging Resources Directory

http://www.researchimaging.pitt.edu

This website provides searchable directory of the imaging resources and capabilities available to biomedical researchers at the University of Pittsburgh and Carnegie Mellon University.

Imaging Resources

  • Biological Sciences Microscopy and Imaging Facility
  • Center for Biologic Imaging (Oakland site)
  • Center for Ultrasound Molecular Imaging and Therapeutics
  • Department of Neurobiology Microscopes
  • Department of Structural Biology Cryo-electron Microscopy (CryoEM) Facility
  • Division of Laboratory Animals Research (DLAR) Imaging
  • Drug Discovery Institute (UPDDI) - High Content Screening (HCS) Imaging Resources
  • Laboratory of Physical Molecular Biology (chromatin fiber imaging)
  • Magnetic Resonance Research Center (MRRC)
  • Near Infrared Spectroscopy (NIRS) Brain Imaging Laboratory
  • Neuroscience Imaging Center (NIC)/Neuroimaging Laboratory, McGowan Institute of Regenerative Medicine
  • Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute Small Animal Ultrasonography Core
  • Positron Emission Tomography (PET) Facility
  • Rangos Research Center Animal Imaging Core Facility, Children’s Hospital of Pittsburgh of UPMC
  • Rangos Research Center Cell Imaging Core I and II Laboratories, Children’s Hospital of Pittsburgh of UPMC
  • Structural Biology Nuclear Magnetic Resonance (NMR) Facility
  • UPMC Hillman Cancer Center Cell and Tissue Imaging Facility (CTIF)
  • UPMC Hillman Cancer Center In Vivo Imaging Facility (IVIF) - Preclinical PET and PET-CT
  • UPMC Hillman Cancer Center In Vivo Imaging Facility (IVIF) – Preclinical MRI
  • UPMC Hillman Cancer Center In Vivo Imaging Facility (IVIF) – Preclinical Optical Imaging
  • UPMC Hillman Cancer Center In Vivo Imaging Facility (IVIF) – Preclinical Ultrasound Imaging

Brain Bank, Neuropathology

Room S701 Scaife Hall
3550 Terrace Street
412-624-9415
412-624-5610
http://neuro.pathology.pitt.edu/brainbank.htm

The Neuropathology Brain Bank at the University of Pittsburgh School of Medicine provides brain only autopsies for deceased pediatric or adult individuals who died with dementia, brain injury, or other neurological diseases. The brain bank has been established over 30 years ago and has accumulated >1000 neurodegenerative cases. Funds from the University of Pittsburgh Brain Institute have allowed us to broaden and expand our banking efforts. All cases receive a full diagnostic evaluation by a board-certified neuropathologist. Some portions of the brain tissue are banked and are made available to local, national and international investigators for qualified research studies. You may make a request by submitting a “Request for Tissue Specimen” at the website or by contacting us.

Center for Research on Health Care, Data Center

Suite 200
200 Meyran Avenue
412-692-2023
F: 412-246-6954
Website

The CRHC Data Center mission is to support University of Pittsburgh faculty members in conducting high-quality clinical and translational research at the University of Pittsburgh. To meet this objective, the CRHC Data Center provides data management, statistical analysis, and graphics services to all University investigators.

The Food and Drug Administration (FDA) developed guidelines (Title 21 CFR Part 11) for electronic records to ensure the integrity and reliability of the electronic data; the CRHC Data Center creates databases that are compliant with these FDA guidelines.

Clinical and Translational Science Institute(CTSI)

Suite 401 Scaife Hall
3550 Terrace Street
412-648-4185
F: 412-648-2741
Website

The mission of the Clinical and Translational Science Institute (CTSI) at the University of Pittsburgh is to improve the efficiency with which biomedical advances translate to improvements in the health of the community. CTSI is transforming the process of clinical and translational research through the provision of research and educational resources, thus training and enabling scientists to generate and translate new biomedical knowledge.

  • Research Participant Registry
  • Regulatory Core
  • Clinical and Translational Research Center
  • Design Biostatistics and Ethics Core

Dietrich School Scientific Stockroom

326 Chevron Science Center
412-624-8551
412-624-8552 (FAX)
WebSite

The Dietriech School Scientific Stockroom (DSS) is an award winning combined stockroom that opened May 20, 2015.  The catalog includes products from the former Biological Sciences, Chemistry, and Physics stockrooms, as well as the Excise Tax Free Ethanol Program all in one convenient location.  It is a University owned and run internal scientific supplier with inventory management support from Unity Lab Services. New suppliers and products are added regularly.  You can pick up your order in the Chevron building or Langley Hall or have them deliver to your building next day.  To Order from the DSS Use the DSS Punch-out on PantherExpress via my.pitt.edu.

 

Pickup locations

326 Chevron Science Center

7:30 a.m. to 5 p.m. Monday - Friday

412-624-8551 or 412-624-4260

 

LANGLEY STATON (alternative stockroom pickup location)

120F Langley Hall/Garage

8 a.m. to 4:30 p.m. Monday - Friday

412-624-4170

Division of Laboratory Animal Resources (DLAR)

412-648-8950
F: 412-648-8449
Website

The Division of Laboratory Animal Resources (DLAR) provides education, training, veterinary and animal husbandry care, and administrative services to support the institution’s animal based research and teaching needs.  The DLAR coordinates efforts to provide a humane, quality animal care program in compliance with legal and regulatory requirements. The programs and facilities are USDA registered, covered under an Assurance with the Office of Lab Animal Welfare (OLAW) of the PHS, and accredited by the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC).  The DLAR forms and guidance documents may be found.  Additional animal care policies may be found on the Institutional Animal Care and Use Committee’s website.

Drug Discovery Institute (UPDDI)

W950 Biomedical Science Tower
200 Lothrop Street
412-648-9200
https://www.upddi.pitt.edu/

Vision for the University of PIttsburgh Drug Discovery Institute: Optimizing the discovery and development of new molecular entities through collaborations between faculty, academic centers, corporations and government agencies, together with innovations focused on Quantitative Systems Pharmacology (QSP).

The UPDDI has three major classes of activities: a) integrated programs that apply QSP to metastatic breast cancer, Huntington’s Disease (as a first focus area to be extended  to other neurodegenerative diseases) and liver diseases; b) projects based on ligand- or target-centric discovery that are driven by faculty collaborators/ RO1 grants covering many therapeutic areas; and c) translational technology development including companion diagnostics, computational biology/chemistry tools, analytics to identify and quantify heterogeneity in experimental and clinical samples and advanced human tissue models for discovery.  The UPDDI is positioned in an outstanding environment to translate key scientific and clinical advances into novel therapeutics.  

Resources include:

Discovery Technology

Chemistry/Medicinal Chemistry

Computational Biology & Chemistry

Zebrafish Facility

Preclinical Resources

Chemical Biology Facility

Epidemiology Data Center

127 Parran Hall, Epidemiology Data Coordinating Center, Graduate School of Public Health
130 DeSoto Street
412-624-5447
F: 412-624-3775
Website

The Epidemiology Data Center (EDC) provides a research environment in which complex health questions can be explored and answered using the combined tools of biology and statistics. The EDC establishes collaborations with clinical researchers to design, conduct, and analyze multi-center randomized clinical trials and epidemiologic studies. To contribute to the development of new knowledge, the EDC develops and refines data collection, data management, computing, and statistical methods, with the ultimate goal of advancing treatment and prevention of disease.

The EDC has collaborated in over 100 research studies sponsored by the National Institutes of Health and other agencies. At any given time the EDC coordinates data management and analysis activities for 20 to 30 research projects sponsored by federal agencies as well as by industry. The current studies represent a variety of scientific designs including clinical trials, registries, and case control studies.

Genome Editing, Transgenic, and Virus Core (GETV)

Formerly the MWRI Transgenic and Molecular Core (TMC)
204 Craft Avenue; Pittsburgh, PA 15213
(412) 641-2415
Website

The Genome Editing, Transgenic and Virus core (GETV) is dedicated to shepherding projects, from vector design to the establishment and maintenance of valuable transgenic/knockout/knockin lines. The core assists investigators by developing state-of-the-art strategies to solve complex biological problems using transgenic, gene editing and viral vector approaches. Directed by Dr. Kyle Orwig and managed by Dr. Yi Sheng, the core provides technical expertise, advice and services for investigators in the University of Pittsburgh community and beyond. Please see the website or contact us for further information or to schedule a face to face meeting to design and implement your experimental plans.

 Core Services

  • Assistance for generating recombinant plasmids;
  • Design and implementation of CRISPR/Cas9 technology for in vivo and in vitro work;
  • Mouse and rat transgenesis, including transgenic and knockout/knockin techniques using pronuclear injection, ES cell injection/chimera and CRISPR/Cas9-mediated genome editing;
  • Lentivirus, adenovirus and adeno-associated virus vectors;
  • Cryopreserve or re-derive of valuable transgenic/knockout or other rodent lines using sperm or embryos;
  • Additional animal testing and procedures: teratoma and chimera testing to validate putative pluripotent stem cell lines;
  • GETV core services are approved by the Institutional Animal Care and Use Committee (IACUC), the recombinant DNA committee, and the environmental health and safety office of the University of Pittsburgh.

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